Tuesday, June 23, 2015

All together now: yeasts can evolve to form snowflake-like multicellular shapes (Image: Courtesy of Jennifer Pentz, Georgia Tech)

The leap from single-celled life to multicellular creatures is easier than we ever thought. And it seems there's more than one way it can happen.

The mutation of a single gene is enough to transform single-celled brewer's yeast into a "snowflake" that evolves as a multicellular organism.

Similarly, single-celled algae quickly evolve into spherical multicellular organisms when faced with predators that eat single cells.

These findings back the emerging idea that this leap in complexity isn't the giant evolutionary hurdle it was thought to be.

At some point after life first emerged, some cells came together to form the first multicellular organism. This happened perhaps as early as 2.1 billion years ago. Others followed – multicellularity is thought to have evolved independently at least 20 times – eventually giving rise to complex life, such as humans.

But no organism is known to have made that transition in the past 200 million years, so how and why it happened is hard to study.

Special snowflake

Back in 2011, evolutionary biologists William Ratcliff and Michael Travisano at the University of Minnesota in St Paul coaxed unicellular yeast to take on a multicellular "snowflake" form by taking the fastest-settling yeast out of a culture and using it to found new cultures. And then repeating the process. Because clumps of yeast settle faster than individual cells, this effectively selected yeast that stuck together instead of separating after cell division.

The team's latest work shows that this transformation from a single to multicellular existence can be driven by a single gene calledACE2 that controls separation of daughter cells after division, Ratcliff told the 15-19 June Astrobiology Science Conference in Chicago.

And because the snowflake grows in a branching, tree-like pattern, any later mutations are confined to single branches. When the original snowflake gets too large and breaks up, these mutant branches fend for themselves, allowing the value of their new mutation to be tested in the evolutionary arena.

"A single mutation creates groups that as a side effect are capable of Darwinian evolution at the multicellular level," says Ratcliff, who is now at Georgia Tech University in Atlanta.

Bigger is better

Ratcliff's team has previously also evolved multicellularity in single-celled algae calledChlamydomonas, through similar selection for rapid settling. The algal cells clumped together in amorphous blobs.

Now the feat has been repeated, but with predators thrown into the mix. A team led byMatt Herron of the University of Montana in Missoula exposed Chlamydomonas to a paramecium, a single-celled protozoan that can devour single-celled algae but not multicellular ones.

Safety in even numbers (Image: Jacob Boswell)

Sure enough, two of Herron's five experimental lines became multicellular within six months, or about 600 generations, he told the conference.

This time, instead of daughter cells sticking together in an amorphous blob as they did under selection for settling, the algae formed predation-resistant, spherical units of four, eight or 16 cells that look almost identical to related species of algae that are naturally multicellular.

"It's likely that what we've seen in the predation experiments recapitulates some of the early steps of evolution," says Herron.

Neither Ratcliff's yeast nor Herron's algae has unequivocally crossed the critical threshold to multicellularity, which would require cells to divide labour between them, says Richard Michod of the University of Arizona in Tucson.

But the experiments are an important step along that road. "They're opening up new avenues for approaching this question," he says.

One gene may drive leap from single cell to multicellular life

Will more sensory substitution devices hit the market soon?

The BrainPort V100

Courtesy Wicab, Inc.

Last week, the Food and Drug Administration (FDA) announced that medical device company Wicab is allowed to market a new device that will help the blind “see.” The device, called theBrainPort V100, can help the blind navigate by processing visual information and communicating it to the user through electrodes on his tongue. Though this isn’t the first device to go on the market using sensory substitution (where information perceived by one sense is communicated through another), the sophistication and usability of the BrainPort V100 could mean that the number of sensory substitution devices permitted by the FDA is on the rise.

The BrainPort V100 consists of a pair of dark glasses and tongue-stimulating electrodes connected to a handheld battery-operated device. When cameras in the glasses pick up visual stimuli, software converts the information to electrical pulses sent as vibrations to be felt on the user’s tongue. Like most sensory substitution devices, “seeing” with your tongue may not be intuitive at first. But the researchers who developed the device tested it over the course of a year, training users to interpret the vibrations. Studies showed that 69 percent of the test subjects were able to identify an object using the BrainPort device after a year of training. However, the device is expensive; Wicab toldPopular Science that it will cost $10,000 per unit, the same as its price when first reported back in 2009.

Researchers have been fiddling withsensory substitution for a long time, but most of these devices are not yet widely available. The BrainPort V100 will be on one of the first, having passed the FDA’s review through recently-updated guidelines called the premarket review pathway: “a regulatory pathway for some low- to moderate-risk medical devices that are not substantially equivalent to an already legally-marketed device,” according to the press release. Since this device is now allowed to be marketed and was approved relatively quickly through these new guidelines, the BrainPort may be paving the way for an explosion of sensory substitution devices to hit the market in the next few years, which could help the growing numbers of Americans with sensory impairments.

Device That Helps Blind People See With Their Tongues Just Won FDA Approval

Technology can reconstruct video based on a person's thoughts and even anticipate your moves while you drive. Now, a brain-to-text system can translate brain activity into written words.

In a recent study in Frontiers in Neuroscience, seven patients had electrode sheets placed on their brain which collected neural data while they read passages aloud from the Gettysburg Address, JFK’s inaugural speech, and Humpty Dumpty.

As each patient spoke, a computer algorithm learned to associate speech sounds—such as "foh", "net", and "ik"—with different firing patterns in the brain cells. Eventually it learned to read the brain cells well enough that it could guess which sound they were producing with up to 75 percent accuracy. But the program doesn't need 100 percent accuracy to put those sounds together into the word "phonetic". Because our speech only takes certain forms, the system’s algorithm can correct for these errors “just like autocorrect,” says Peter Brunner, one of the co-authors of the study.

“Siri wouldn’t be more accurate than 50 or 70 percent,” he says. “Because it knows what the potential options are that you choose, or the typical sentences that you say, it can actually utilize this information to get the right choice.”

It is important to record the data directly from the brain, says Brunner, because picking up neural activity from the scalp only gives a “blurred version” of what is happening in the brain. He likened the latter method to flying 1000 feet above a baseball stadium and only being able to vaguely recognize that people are cheering, but not the specifics of what the people’s faces look like.

In this case, the patients were already undergoing an epilepsy procedure where the skull is popped open and an electrode grid is placed on the brain to map areas where neurons are misfiring. The resourceful team of researchers from the National Center for Adaptive Neurotechnologies and the State University of New York at Albany used this time to conduct their own research. However, it means study was limited by each patient’s individualized epilepsy treatment, such as where the electrodes were placed on the brain.

Because every person’s brain is so unique, and the neural activity must be picked up directly from the brain, it would be difficult to create a general brain-to-text device for the average consumer, says Brunner. However, this technology has a lot of potential to be used for people who suffer from neurological diseases, such as ALS, who lose the ability to move and to speak. Instead of using an external device like Steven Hawking to pick out words on a screen for a computer to read, the computer would simply speak your mind.

“This is just the beginning,” said Brunner. “The prospects of this are really endless.”

Mind-Reading Program Translates Thoughts Into Text

Monday, June 22, 2015


Source: Google

Let's face it... America is crazy for apps. According to ratings company Nielsen, the average U.S. smartphone user spends 37.5 hours every month playing games, browsing social media, or consuming news through apps.

Not only is that a significant amount of time, it's quickly increasing. Overall, the company found that time spent on apps more than doubled from 18.3 hours a month in Q4 2011 to the aforementioned 37.5 in Q4 2014, which is good for an annualized growth figure of 27%.

On the surface, this sounds like good news for both major operating systems -- Google's(NASDAQ: GOOGL) (NASDAQ: GOOG) Android and Apple's (NASDAQ: AAPL) iOS -- as it portends growing importance for app gatekeepers and ecosystems. Look more deeply into the data, however, and the proliferation of apps is decidedly better for one company than the other... and it isn't the company that makes the majority of its revenue from search.

Even with the majority of the mobile OS market, Google is a search company
Google commanded a massive 1.6 billion smartphone installed base as of year-end 2014, good for 76% market share and leading Apple's total of 410 million smartphones. But that's not how Google makes the majority of its money. Looking at the last fiscal year, the company reported $66 billion in total revenue, with $59 billion of that coming from advertising and search. The remainder -- roughly $7 billion -- is reported in a catch-all "other revenues" figure, which includes revenue from apps and content from the Google Play store.

Here's the conundrum: While Google has the largest app store by sheer subscriber numbers, the company receives the majority of its money from advertising and search-based revenues. For an interesting corollary, investment firmGoldman Sachs estimated that in 2014, Googlemade more in mobile search revenue from Apple's iOS than it made from its own app store and mobile search, combined.

As a matter of fact, eMarketer (via Business Insider) estimates that $38 billion of Google's total revenue -- nearly 60% -- comes directly from search. And considering that very few apps utilize any search features at all, the migration toward an apps-based Internet experience, and away from web browsing, presents a headwind of sorts for Big G.

Google's attempt to lessen app dependence
According to Amir Efrati from the website The Information, Google's not taking this threat lightly. The search giant quietly acquired Agawi last year. This company's technology allows smartphone users to access an app on the web via streaming without having to download the actual app. And while there are a few other reasons to buy the technology -- most notably, to save internal phone storage -- the most plausible reason for the purchase is to keep smartphone users from downloading apps.

Is this technology a game changer? Who knows; but the fact that the technology was purchased last year, and is just now being reported, points to the fact that more development or integration is needed. In addition, it now appears that Google is working more closely with app developers to improve its mobile search experience.

The key here is that Google is working on reducing the growing dependence on apps, while also working harder to monetize app-based browsing -- all good news for long-term investors.

The next billion-dollar Apple secret
Apple forgot to show you something at its recent event, but a few Wall Street analysts and the Fool didn't miss a beat: There's a small company that's powering Apple's brand-new gadgets and the coming revolution in technology. And its stock price has nearly unlimited room to run for early in-the-know investors! To be one of them, just click here.

The End of the "Made-In-China" Era 
The 21st century industrial revolution has already begun. Business Insider calls it "the next trillion dollar industry". A new investment video reveals the impossible (but real) technology that could make you impossibly rich. Simply enter your email address below to see the surprise ending:

Google Attacks Its Own App Store With Its Newest Acquisition

Sunday, June 21, 2015

#Diet #Health – New 5-Day ‘Fasting’ Diet Seems To Lower Disease Risk, Slow Aging – 

The new Fasting Mimicking Diet (FMD), developed by university researchers is under human trials in the United States. The new diet produces the best results when people starve by cutting calories for five days in a row. The “fasting” diet could help to produce results such as weight loss; better immune system; lower risk of cancer, heart disease and diabetes; and looking younger.

Researchers at the University of Southern California (USC) created the diet. They stated that most people would only stick to the diet plan four times every year. One of the benefits of the new diet is that there is no need for calorie reduction.  Significant lowering of caloric intake can result in people often feeling hungry and getting moody.

Dr. Valter Longo is a USC professor. He is also one of the main developers of the new fasting method.The findings of Longo’s recent study were published this week in the journal Cell Metabolism.

In the laboratory research, old mice were placed in cycles of a low-calorie diet for four days. The dieting effects included belly fat loss, more stem cells in many organs, and improved memory, according Tech Times. A human trial of FMD included 19 humans who completed a monthly “fast,” according to The Telegraph.  The fasting diet lasted 5 days.

New 5-Day ‘Fasting’ Diet Seems To Lower Disease Risk, Slow Aging

In 1850, the Reverend Thomas Kirkman, rector of the parish of Croft-with-Southworth in Lancashire, England, posed an innocent-looking puzzle in the Lady’s and Gentleman’s Diary, a recreational mathematics journal:

“Fifteen young ladies in a school walk out three abreast for seven days in succession: it is required to arrange them daily, so that no two shall walk twice abreast.” (By “abreast,” Kirkman meant “in a group,” so the girls are walking out in groups of three, and each pair of girls should be in the same group just once.)

Solve a variation of Thomas Kirkman’s puzzle by arranging nine girls in walking groups. And think fast—the clock is ticking. Emily Fuhrman for Quanta Magazine, with design by Olena Shmahalo. Collage resources from The Graphics Fairy and and Clker.

Pull out a pencil and paper, and you’ll quickly find that the problem is harder than it looks: After arranging the schoolgirls for the first two or three days, you’ll almost inevitably have painted yourself into a corner, and have to undo your work.

The puzzle tantalized readers with its simplicity, and in the years following its publication it went viral, in a slow, modestly Victorian sort of way. It generated solutions from amateurs (here’s one of seven solutions) and papers by distinguished mathematicians, and was even turned into a verse by “a lady,” that begins:

Quanta Magazine

About

Original story reprinted with permission fromQuanta Magazine, an editorially independent division of SimonsFoundation.org whose mission is to enhance public understanding of science by covering research developments and trends in mathematics and the physical and life sciences.

A governess of great renown,
Young ladies had fifteen,
Who promenaded near the town,
Along the meadows green.

While Kirkman later bemoaned the fact that his weightier mathematical contributions had been eclipsed by the popularity of this humble brainteaser, he was quick to defend his territory when another prominent mathematician, James Joseph Sylvester, claimed to have created the problem “which has since become so well-known, and fluttered so many a gentle bosom.”

The puzzle may seem like an amusing game (try a simpler version here), but its publication helped launch a field of mathematics called combinatorial design theory that now fills gigantic handbooks. What started as an assortment of conundrums about how to arrange people into groups—or “designs,” as these arrangements came to be called—has since found applications in experiment design, error-correcting codes, cryptography, tournament brackets and even the lottery.

Yet for more than 150 years after Kirkman circulated his schoolgirl problem, the most fundamental question in the field remained unanswered: Do such puzzles usually have solutions? Kirkman’s puzzle is a prototype for a more general problem: If you have n schoolgirls, can you create groups of size k such that each smaller set of size t appears in just one of the larger groups? Such an arrangement is called an (nkt) design. (Kirkman’s setup has the additional wrinkle that the groups must be sortable into “days.”)

Thomas Kirkman’s popular math puzzle was first published in the 1850 edition of the Lady’s and Gentleman’s Diary. Hathi Trust

It’s easy to see that not all choices of nk and twill work. If you have six schoolgirls, for instance, you can’t make a collection of schoolgirl triples in which every possible pair appears exactly once: Each triple that included “Annabel” would contain two pairs involving her, but Annabel belongs to five pairs, and five is not divisible by two. Many combinations of nk and t are instantly ruled out by these sorts of divisibility obstacles.

For the parameters that aren’t ruled out, there’s no royal road to finding designs. In many cases, mathematicians have found designs, through a combination of brute force and algebraic methods. But design theorists have also found examples of parameters, such as (43, 7, 2), that have no designs even though all the divisibility requirements check out. Are such cases the exception, mathematicians wondered, or the rule? “It was one of the most famous problems in combinatorics,” said Gil Kalai, a mathematician at the Hebrew University of Jerusalem. He recalls debating the question with a colleague a year and a half ago, and concluding that “we’ll never know the answer, because it’s clearly too hard.”

Just two weeks later, however, a young mathematician named Peter Keevash, of the University of Oxford, proved Kalai wrong. In January 2014, Keevash established that, apart from a few exceptions, designs will always exist if the divisibility requirements are satisfied. In asecond paper posted this April on the scientific preprint site arxiv.org, Keevash showed how to count the approximate number of designs for given parameters. This number grows exponentially—for example, there are more than 11 billion ways to arrange 19 schoolgirls into triples so that each pair appears once.

The result is “a bit of an earthquake as far as design theory is concerned,” said Timothy Gowers, a mathematician at the University of Cambridge. The method of the proof, which combines design theory with probability, is something no one expected to work, he said. “It’s a big surprise, what Keevash did.”

Winning Big

Mathematicians realized in the early days of design theory that the field was intimately connected with certain branches of algebra and geometry. For instance, geometric structures called “finite projective planes”—collections of points and lines analogous to those in paintings that use perspective—are really just designs in disguise. The smallest such geometry, a collection of seven points called the Fano plane , gives rise to a (7, 3, 2) design: Each line contains exactly three points, and each pair of points appears in exactly one line. Such connections gave mathematicians a geometric way to generate specific designs.

The geometric structure called a “Fano plane” corresponds to a (7, 3, 2) design. Gunther

In the 1920s, the renowned statistician Ronald Fisher showed how to use designs to set up agricultural experiments in which several types of plants had to be compared across different experimental conditions. Today, said Charles Colbourn, a computer scientist at Arizona State University in Tempe, “one of the main things [experiment-planning software] does is construct designs.”

Starting in the 1930s, designs also became widely used to create error-correcting codes, systems that communicate accurately even when information must be sent through noisy channels. Designs translate neatly into error-correcting codes, since they create sets (groups of schoolgirls) that are very different from each other—for instance, in the original schoolgirl problem, no two of the schoolgirl triples contain more than a single girl in common. If you use the schoolgirl groups as your “code words,” then if there’s a transmission error as you are sending one of the code words, you can still figure out which one was sent, since only one code word will be close to the garbled transmission. The Hamming code, one of the most famous early error-correcting codes, is essentially equivalent to the (7, 3, 2) Fano plane design, and another code related to designs was used to encode pictures of Mars that the Mariner 9 probe sent back to Earth in the early 1970s. “Some of the most beautiful codes are ones that are constructed from designs,” Colbourn said.

Design theory may even have been used by betting cartels that made millions of dollars off of Massachusetts’ poorly designed Cash WinFall lottery between 2005 and 2011. That lottery involved choosing six numbers out of 46 choices; tickets won a jackpot if they matched all six numbers, and smaller prizes if they matched five out of six numbers.

There are more than 9 million possible ways to pick six numbers out of 46, so buying tickets with every possible combination would cost far more than the game’s typical jackpot. A number of groups realized, however, that buying hundreds of thousands of tickets would enable them to turn a profit by scooping up many of the smaller prizes. Arguably the best assortment of tickets for such a strategy is a (46, 6, 5) design, which creates tickets of six numbers such that every set of five numbers appears exactly once, guaranteeing either the jackpot or every possible five-number prize.

No one has found a (46, 6, 5) design so far, Colbourn said, but designs exist that are close enough to be useful. Did any of the betting cartels use such a design “to siphon money from the Lottery at no risk to themselves?” wroteJordan Ellenberg, a mathematician at the University of Wisconsin, Madison, who discussed the Cash WinFall lottery in his book How Not to Be Wrong. If they didn’t, Ellenberg wrote, they probably should have.

It would be hard to make a complete list of the applications of designs, Colbourn said, because new ones are constantly being discovered. “I keep being surprised at how many quite different places designs arise, especially when you least expect them,” he said.

A Perfect Design

As the number of design applications exploded, mathematicians filled reference books with lists of designs that might someday prove useful. “We have tables that say ‘For this set of parameters, 300,000 designs are known,’” said Colbourn, a co-editor of the 1,016-page Handbook of Combinatorial Designs.

Peter Keevash of the University of Oxford. Peter Keevash

Despite the abundance of examples, however, mathematicians struggled to get a handle on just how often designs should exist. The only case they understood thoroughly was the one in which the smallest parameter, t, equals 2:Richard Wilson, of the California Institute of Technology in Pasadena, showed in the mid-1970s that when t = 2, for any k there is at most a finite number of exceptions—values of n that satisfy the divisibility rules but don’t have designs.

But for t greater than 2, no one knew whether designs should usually exist—and for values of tgreater than 5, they couldn’t even find a single example of a design. “There were people who felt strongly that [designs] would exist, and others who felt strongly that it’s too much to ask for,” Colbourn said.

In 1985, Vojtěch Rödl of Emory University in Atlanta offered mathematicians a consolation prize: He proved that it’s almost always possible to make a good approximate design—one that perhaps is missing a small fraction of the sets you want, but not many. Rödl’s approach uses a random process to gradually build up the collection of sets—a procedure that came to be known as the Rödl nibble, because, as Keevash put it, “instead of trying to swallow everything at once, you just take a nibble.”

Since then, the Rödl nibble has become a widely used tool in combinatorics, and has even been used in number theory. Last year, for example, mathematicians used it to help establish how far apart prime numbers can be.

But mathematicians agreed that the nibble wouldn’t be useful for attempts to make perfect designs. After all, at the end of Rödl’s procedure, you will typically have missed a small fraction of the smaller sets you need. To make a perfect design, you’d need to add in some additional larger groups that cover the missing sets. But unless you’re very lucky, those new larger groups are going to overlap with some of the groups that are already in your design, sending new errors cascading through your system.

Designs just didn’t seem to have the kind of flexibility that would allow a random approach to work. It seemed “obviously impossible,” Gowers said, that an approach like Rödl’s could be used to make perfect designs.

Last year, however—nearly three decades after Rödl’s work—Keevash showed that it is possible to control the cascade of errors by using an approach that marries flexibility and rigidity. Keevash modified Rödl’s construction by starting off the nibble with a specific collection of schoolgirl groups, called a “template,” that has particularly nice algebraic properties. At the end of the nibble, there will be errors to correct, but once the errors propagate into the template, Keevash showed, they can almost always be fixed there in a finite number of steps, producing a perfect design. “The full proof is extremely delicate and it is a phenomenal achievement,”wrote Ross Kang, of Radboud University in the Netherlands.

“I think a few years ago, nobody thought that a proof was on the horizon,” Colbourn said. “It’s an extraordinary breakthrough.”

For pure mathematicians, Keevash’s result is in a sense the end of the story: It establishes that for any parameters t and k, all values of n that fit the divisibility conditions will have a design, apart from at most a finite number of exceptions. “It sort of kills off a whole class of problems,” Gowers said.

But Keevash’s result leaves many mysteries unsolved for people who care about actual designs. In theory, his template-nibble approach could be used to create designs, but for now it’s unclear how large n has to be for his method to work, or how long an algorithm based on his method would take to run. And while Keevash has proved that designs almost always exist, his result doesn’t say whether a design will exist for any particular set of parameters you might care about. “People will presumably still work on this for generations,” Wilson said.

An illustration of the nine prisoners problem from Martin Gardner’s book The Last Recreations. Martin Gardner / Springer Science+Business Media

Still, Keevash’s result will shift the mindset of mathematicians who are trying to find designs, Colbourn said. “Before, it wasn’t clear whether the focus should be on constructing designs or proving they don’t exist,” he said. “Now at least we know the effort should focus on constructing them.”

And the shortage of information about specific designs leaves plenty of fun puzzles for recreational mathematicians to solve. So in the spirit of Kirkman, we will leave the gentle reader with another brainteaser, a slight variation on the schoolgirl puzzle devised in 1917 by the British puzzle aficionado Henry Ernest Dudeney and later popularized by Martin Gardner: Nine prisoners are taken outdoors for exercise in rows of three, with each adjacent pair of prisoners linked by handcuffs, on each of the six weekdays (back in Dudeney’s less enlightened times, Saturday was still a weekday). Can the prisoners be arranged over the course of the six days so that each pair of prisoners shares handcuffs exactly once?

Dudeney wrote that this puzzle is “quite a different problem from the old one of the Fifteen Schoolgirls, and it will be found to be a fascinating teaser and amply repay for the leisure time spent on its solution.” Happy solving!

Original story reprinted with permission fromQuanta Magazine, an editorially independent publication of the Simons Foundation whose mission is to enhance public understanding of science by covering research developments and trends in mathematics and the physical and life sciences.

Answer to a 150-Year-Old Math Conundrum Brings More Mystery

Saturday, June 20, 2015

In order to understand how the organ selectively transmits cells from mother to child

A placenta on a chip device

Courtesy of the Eunice Kennedy Shriver National Institute of Child Health and Human Development

From lungs to brains, organ tissues grown on a lab are telling researchers a lot about how their cells do their jobs. Now researchers are using the technology to better understand the placenta, the temporary organ that connects a fetus and mother during pregnancy.

The placenta’s primary function is to act as a “crossing guard” between mother and child—it sends the good stuff (like nutrients and oxygen) along to the baby, while leaving other damaging elements like chemicals from environmental exposure or disease-causing bacteria or viruses. If the placenta is damaged or doesn’t work right, it could endanger the health of both the mother and the baby.

Researchers don’t really know how the placenta is able to transmit the good things while keeping out the bad. That’s because the placenta is notoriously difficult to study in humans—it takes a long time, varies a lot between individual patients, and could put the fetus’ safety at risk. In the past, most studies about the placenta were done in animals to work around these issues. Animal studies have shed some light on how the placenta works, but the tissue is never quite the same as in humans.

A rendering of the placenta on a chip

Scientists Are Growing A Human Placenta On A Chip

Friday, June 19, 2015


The Apple Watch is barely two months old, but details are already starting to come out about what's planned for the next model. 9to5Macreports that Apple is currently planning to put a camera for video chatting on the top bezel of the Watch. It may also gain more independence from the iPhone by including a new wireless chip that would allow the Watch to use Wi-Fi to handle more advanced tasks. Apple is also said to be satisfied with the Watch's battery life and not focused on improving it for the next model. The report warns that Apple's current plans could be scrapped and saved for future models, depending on how development goes.

Video chatting sounds futuristic but frustrating

The addition of a video camera to the Watch is, arguably, a strange next step. While video chatting on a smartwatch certainly has a wonderfully futuristic vibe that could help to sell the new model, it could have significant downsides, including rapidly draining the Watch's battery, requiring an awkward arm position for an extended period of time, and only displaying the video on a very small screen. Of course, Apple also made the inclusion of front-facing smartphone cameras explode, so it's not worth counting this idea out based on the concept alone. Samsung has previously included a camera in a smartwatch, although it was oriented for taking photos.

Including more capable wireless abilities in the next Watch is certainly an important addition. The Watch is currently quite limited because it pretty much always needs to be paired to an iPhone over Bluetooth in order to work. It can currently do some functions over Wi-Fi, but it's largely meant as a backup — not as a way to use the Watch without a phone. It's not clear how much of that would change with an update to the Watch, but any alterations that let it grow a bit more independent are still meaningful and convenient steps forward.

Apple's customer research has apparently indicated that people are satisfied with the Watch's battery life, 9to5Mac reports. It's true that the Watch, typically, does make it through the day. But, much like the iPhone, if you actually decide to use the Watch in a significant way one day, there's a good chance that it'll run out quickly — and it's pretty rough having a dead Watch on your wrist. It's not entirely surprising then that Apple is trying to focus on new features while maintaining the Watch's existing battery life, but it would be nice to see improvement in that area in the future.

New high-end models could sit beneath the gold Editions

In addition to the new features, 9to5Mac reports that Apple is considering making a new high-end version of the Watch. It could be either an extension of the Apple Watch line or a new line that sits above the Apple Watch but well below the Edition. Apple reportedly wants to target people willing to spend more than $1,000, but not quite the $10,000 or so needed to buy a gold Edition. These new models could be the standard Apple Watch with new bands, or they could be part of a new line made with different materials, the report suggests.

There's been no real suggestion of when Apple will release the next version of the Watch, but it's likely that it won't be until next year. Apple typically updates its products on a one-year cycle, and the Watch is still only months old. It probably won't be ready for a refresh this fall, either, even when Apple releases watchOS 2, which brings with it support for native third-party apps. The updated software includes a number of other new features, including support for third-party complications, which could pretty quickly make the Watch a lot more useful.

Correction: This article previously stated that the Watch was incapable of updating apps like Weather over Wi-Fi. It can, so long as the network is already known through a paired iPhone.

The next Apple Watch could have a FaceTime camera

Researchers have built devices that harness changes in atmospheric humidity to generate small amounts of electricity, lift tiny weights, and even power a toy car. In the grand scheme of things, that captured energy is not free, but it’s pretty darn close. The study suggests that evaporation could be used to operate a variety of gadgets that don’t require a lot of power, scientists say.

“This is one of the first experiments to show that humidity can be a source of fuel,” says Albert Schenning, a materials scientist at the Eindhoven University of Technology in the Netherlands who wasn’t involved in the new study. The team’s designs, he says, “are very nice and very clever.”

All the gadgets rely on a simple phenomenon—the change in size of bacterial spores as they absorb moisture from the air and then release it, says team leader Ozgur Sahin, a biophysicist at Columbia University. Sahin and his colleagues used the living but dormant spores from Bacillus subtilis, a species of bacteria commonly found in soil and in the human gastrointestinal tract. Each spore typically swells and then shrinks up to 6% when moved from dry air to extremely humid air and then back again, Sahin says. The researchers harnessed that size-changing action by gluing thin layers of spores onto one side of curved sheets of polymer. When the spores swelled, that side of the polymer sheet lengthened—which in turn caused the curved sheet to somewhat straighten out. The stretching and contracting of these spore-coated polymer sheets are the driving force for the team’s devices.

A change in size of 6% may not sound that impressive. But when the researchers strung together a series of these polymer sheets, the “artificial muscles” they created quadrupled in length when relative humidity changed from below 30% to more than 80%, the team reports today in Nature Communications.  

The thicker the spore layer, the longer it would take for the muscles to react to changes in humidity. So, to make sure their artificial muscles were quick-acting, the researchers used spore layers that were extremely thin—no more than 3 micrometers thick, or about 5 spores deep on average, Sahin says. Tests showed that the devices could react to humidity changes within 3 seconds, he notes.

Tests also revealed that the spore-coated polymer strips could expand and shrink for more than 1 million cycles with little change in their range of motion. Other trials showed that the strips, when they shrank, could lift more than 50 times their own weight (video). But they did so much more slowly than an animal’s muscle would, so the power they generated—that is, their rate of energy production—was correspondingly low.

Nevertheless, the team harnessed changes in humidity to perform actual work. In one device, the back-and-forth motion driven by one artificial muscle suspended above a postage stamp–sized patch of water provided enough electrical power to light an LED. In another, the expansion of muscles on one side of a Ferris wheel–like device (where the air was humidified by evaporation from a wet paper towel) but not the other triggered an imbalance that caused the wheel to rotate (video). The team used the motion of a similar wheel to power a 100-gram toy car(video).

“These are fun demonstrations, but they prove the principle,” says Peter Fratzl, a materials scientist at the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany, who was not involved with the work. Researchers are constantly looking for sources of energy, even if they’re small, he notes. “It makes sense to use these gradients [in humidity], because they’re everywhere and they’re free.”

The team’s results are a good conceptual starting point, says George Whitesides, a chemist at Harvard University. Such devices could, in theory, generate enough electricity to run a few transistors, he adds. “But it will still be a while before these things are in every child’s bathtub.”

Energy harnessed from humidity can power small devices

After years of fasting, the Buddha’s “legs were like bamboo sticks, his backbone was like a rope, his chest was like an incomplete roof of a house, his eyes sank right inside, like stones in a deep well,” according to one account. The Buddha didn’t get what he wanted from this extreme fasting—enlightenment—but a new study suggests that a diet that replicates some effects of milder deprivation may not only lower your weight but also confer other benefits. Researchers report that following the diet for just 5 days a month improves several measures of health, including reducing the risk of developing cardiovascular disease.

Eating shortens life, and not just because overindulgence can lead to diseases such as diabetes. A diet that cuts food intake by up to 40%, known as calorie restriction, increases longevity in a variety of organisms and forestalls cancer, heart disease, and other late-life illnesses. Although some short-term studies suggest that calorie restriction provides metabolic benefits to people, nobody has confirmed that it also increases human life span. The closest researchers have come are two large, long-term studies of monkeys, and they conflict about whether meager rations increase longevity.

Even if calorie restriction could add years to our lives, almost no one can muster the willpower to eat so little day after day, year after year. An alternative that might be more, er, palatable is fasting, the temporary abstinence from food. Gerontological researcher Valter Longo of the University of Southern California in Los Angeles and colleagues have shown that fasting eases side effects of chemotherapy such as fatigue and weakness, and animal studies suggest that it produces health advantages similar to calorie restriction.

But hard-core fasting, in which people drink only water for days at a time, may be no easier than calorie restriction. “I’ve done it, and it was excruciating,” Longo says. For the new study he and his colleagues devised a less grueling diet that might still trigger the benefits of fasting. For two 4-day periods each month, middle-aged mice dined on low-protein, low-calorie chow. The rest of the month, they could nosh as much as they wanted.

The mice outlived their peers by an average of 3 months, a substantial amount for the rodents, and they displayed numerous signs of better health. As the researchers report online today inCell Metabolism, the mice shed fat and were 45% less likely to fall victim to cancer. During their lean cuisine episodes, their level of blood sugar fell by 40% and the amount of insulin in the blood was 90% lower. And although brainpower usually declines with age, the mice retained more of their mental ability; they bested control animals in two kinds of memory tests, perhaps because they produced more new neurons in the hippocampus, a brain area crucial for memory.

Longo and colleagues also uncovered evidence that the regimen boosted the animals’ capacity to restore and replenish their tissues. “That’s the most exciting” finding, Longo says. For instance, regeneration of the liver was quicker in the fasting animals, and the balance of different types of cells in their blood was more youthful. The numbers of certain stem cells also soared in the dieting rodents.

To determine whether occasional austerity might have the same impact on people, the researchers whipped up a menu of energy bars, soups, teas, and chips. One day’s fare furnishes between 725 and 1090 calories. “It’s not like eating ravioli, but it is better than going without,” Longo says. (The average adult man in America needs about 2000 to 3000 calories daily; people following calorie restriction may limit themselves to as few as 1200 calories.)

Much like the mice, the volunteers in the study followed the diet for 5 days straight and then returned to their usual dining habits for the rest of the month. In their paper, the researchers report the results for the first group of 19 subjects to try this “fasting mimicking” regimen and for 19 controls.

Only three rounds of alternating between the diet and normal eating appeared to improve the participants’ physical condition, reducing blood glucose, trimming abdominal fat, and cutting levels of a protein associated with a higher risk of cardiovascular disease. Longo and colleagues also detected a slight rise in the abundance of some stem cells in the blood, suggesting that the diet might promote regeneration in humans. “We think that what the fasting mimicking diet does is rejuvenate,” Longo says.

Other researchers say the results of the study are encouraging. “This single dietary change can counteract all these variables of aging, and I think that’s very impressive,” says molecular biologist Christopher Hine of the Harvard School of Public Health in Boston. The study shows that cutting calories all the time may not be necessary, adds biochemist James Mitchell, also of the Harvard School of Public Health. “Intermittent periods can have lasting effects.”

The new diet may also be more practical. “Calorie restriction has failed miserably in human trials” because it’s so hard to stick to, says gerontologist Rafael de Cabo of the U.S. National Institute on Aging in Baltimore, Maryland, who leads one of the monkey studies of calorie restriction. A regimen like the researchers use “is achievable,” he says.

Longo and colleagues have already completed a larger clinical trial of the diet with more than 80 subjects. Fasting like the Buddha is dangerous, and even the fasting mimicking diet could be harmful for some people, such as diabetics, Longo notes. Researchers need to study how the regimen works, who might benefit, and who might be harmed by it, Mitchell notes. “There is a lot of information to figure out.”

Short-term fasting may improve health

 
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